Here There and Everywhere

From AOL Health News

By Marrecca Fiore Mar 11th 2010 11:23AM

A study from researchers at the University of Florida finds that papaya has a dramatic anticancer effect against a broad range of lab grown tumors such as those that cause liver cancer and lung cancer.

In a paper published in the Feb. 17 issue of the “Journal of Ethnopharmacology,” University of Florida researcher Nam Dang, M.D., Ph.D., and colleagues in Japan say they made a tea using an extract made from dried papaya leaves to fight cancers of the cervix, breast, liver, lung and pancreas. The researchers say the anticancer effects were stronger when cells received larger doses of the tea.

Dr. Dang and his colleagues also documented for the first time that papaya leaf extract boosts the production of key signaling molecules called Th1-type cytokines, which help regulate the immune system. In addition to papaya’s direct antitumor effect on various cancers, the signaling of Th1-type cytokines suggests possible therapeutic strategies that use the immune system to fight cancer, researchers said.

The papaya extract did not have any toxic effects on normal cells, avoiding a common and devastating consequence of many cancer therapy regimens, such as chemotherapy.

The success of the papaya extract in acting on cancer without toxicity is consistent with reports from indigenous populations in Australia and his native Vietnam, said Dang, a professor of medicine and medical director of the UF Shands Cancer Center Clinical Trials Office.

“Based on what I have seen and heard in a clinical setting, nobody who takes this extract experiences demonstrable toxicity; it seems like you could take it for a long time — as long as it is effective,” he said in a statement.

Researchers exposed 10 different types of cancer cell cultures to four strengths of papaya leaf extract and measured the effect after 24 hours. Papaya slowed the growth of tumors in all the cultures.

In a similar analysis, the team also looked at the effect of papaya extract on the production of antitumor molecules known as cytokines. Because the papaya was shown to promote the production of Th1-type cytokines, this raises the possibility of future use of papaya extract components in immune-related conditions such as inflammation, autoimmune disease and some cancers.

Bharat B. Aggarwal, Ph.D., a researcher at the University of Texas M.D. Anderson Cancer Center in Houston, already is so convinced of papaya’s restorative powers that he has a serving of the fruit every day.

“We have always known that papaya has a lot of interesting things in there,” Aggarwal, a professor in the center’s department of experimental therapeutics who was not involved in the UF research, said in a statement.