Early Signs of Alzheimer’s Determined
Scientists have assembled a “timeline” of the unseen progress of Alzheimer’s before symptoms appear.
A team at Washington University School of Medicine looked at families with a genetic risk of the disease.
Writing in the New England Journal of Medicine, they say signs appeared up to 25 years before the expected onset of the disease.
UK experts said the ability to detect Alzheimer’s early would give the best chance of successful treatment.
‘Key changes’
The 128 people in the study, from the UK, US and Australia, had a 50% chance of inheriting one of three mutations that are certain to cause early Alzheimer’s, which often develops in people’s 30s and 40s – much earlier than the more common form of Alzheimer’s which generally affects people in their 60s.
Those who carry the mutations will go on to develop the disease.
The researchers looked at the age the participants’ parents were when they developed the disease – and therefore how many years it was likely to be before they too showed symptoms.
The ability to detect the very earliest stages of Alzheimer’s… would enable new drugs to be trialled in the right people, at the right time”
They underwent blood and spinal fluid tests as well as brain scans and mental ability assessments.
The earliest change – a drop in spinal fluid levels of the key ingredient of Alzheimer’s brain plaques – can be detected 25 years before the anticipated age of disease onset, they suggest.
At 15 years, raised levels of tau, a structural protein in brain cells can be seen in spinal fluid – and shrinkage can also be detected within parts of the brain.
Changes in the brain’s use of the sugar glucose and slight memory problems become apparent 10 years before symptoms would appear, they suggest.
Researchers also tested other members of the families without the inherited mutations – and found no changes in the markers they tested for.
Prof Clive Ballard, director of research at the Alzheimer’s Society, said: “This important research highlights that key changes in the brain, linked to the inherited form of Alzheimer’s disease, happen decades before symptoms show, which may have major implications for diagnosis and treatment in the future.
“These findings are a good indicator that there may be key changes in the brain happening early in people who develop non-hereditary Alzheimer’s disease, but we can’t be sure. Further research into this complex condition is needed to confirm a definite link.”
And Dr Eric Karran, director of Research at Alzheimer’s Research UK, said: “These results from people with the inherited form of Alzheimer’s seem to be very similar to the changes in the non-genetic, common form of the disease.
“It’s likely that any new treatment for Alzheimer’s would need to be given early to have the best chance of success.
“The ability to detect the very earliest stages of Alzheimer’s would not only allow people to plan and access care and existing treatments far sooner, but would also enable new drugs to be trialled in the right people, at the right time.”
Scam for today: Libya
In my e-mail this morning, another scam letter, this one purporting to be Libyan money. (If I were a scammer, I would hope I would write a scam letter which made more sense):
Greetings
I’m sorry that this mail will come to you as a surprise, my name is Mr.Chris Allen and I’m the personal assistant to Former Libyan oil Chief Shukri Ghanem whose body was found dead in the Danube river near Vienna recently.During his office days I was sent for a mission in Accra Ghana to lodge a huge amount of money in the tune of $26million united state dollars with a private security firm for safe keeping/investment purpose, the fund in question belongs to Libyan investment authority (L.I.A).
Now this is where I am seeking for your assistance to help me secure/stand as the beneficiary of the estate related documents shall be transferred to your name as sole beneficiary for an investment in your country terms/modalities shall be discussed upon your reply, If you are to be trusted regards to confidentiality.
Once we open communication I will provide you with more details.
Expecting your urgent response.
Chris Allen
global.a2016@att.net
“Are you Happy?”
(Thank you, AdventureMan, for this wonderful photo)
“Are you happy?” our little happy boy asked his Daddy, and burst into tears when his Daddy told him no, he was sad that his little boy was hitting his Mama.
It’s a funny age, two-and-a-half, discovering all the things you are able to do, no longer a baby. The happy little boy is learning to swim, and he loves running. He is in the midst of potty training. He gets to spend the night with his grandparents, and in August he will go to Cousin’s Camp! He is also not happy with limits – but then, who is? It’s a tough time to be a parent, or a grandparent, when this delightful little boy digs his heels in about an issue.
“The secret is to negotiate,” our son told AdventureMan over lunch. “You have to find a way that he can back down without losing. Distraction works, or a compromise that isn’t even a compromise.”
LOL; that’s exactly what I did with him! My Mother used to say “You’re the mother! Just tell him he has to do it because you say so! Make him mind you!”
In our nomadic life, I needed a child who would cooperate. When you cooperate, two – or more – people have to cooperate, that means the parent, too. Our son grew up as a part of a team that had to operate together for the good of all. We still operate that way.
My generation did things differently; we explained, we negotiated, we compromised, we listened. I look at our son, and his cousins, and I feel enormously proud; we raised a generation of outstanding adults who are wonderful loving and compassionate parents to their children.
I am happy. AdventureMan is taking the Happy Little Boy to swim lessons this morning, then to the Naval Aviation Museum, which the Happy Little Boy LOVES! And the Happy Grandmother gets to quilt!
Hot Rain For Pensacola Blue Angels
It’s the biggest week for Pensacola and Pensacola Beach, it’s Blue Angels week, and people come from all over the USA to watch our home team do arial acrobatics. It’s always a thrill, driving to an appointment, when suddenly the Blue Angels appear in the sky, flying in close formation. Their practices are a weekly delight to Pensacolians.
It’s a funny week, though, a week when we have had rain almost every day. It makes summer in Pensacola different from summer in Kuwait and Qatar. In Pensacola, rain is a good thing, sometimes we don’t get enough. This year, we have been deluged; one area of our city flooded while we were in Zambia, and even our house suffered from the hurricane-force wind-driven rain.
It’s not a cold rain, it’s a hot rain, the rain falls and the temperatures are in the 90’s, falling to the high 80’s. We are planning to go out to the beach to watch the big practice on Friday (we do not plan to go for the full show on Saturday! Maybe someday when we can book a hotel room for that time) hoping the beach breezes keep the mosquitos at bay. Thundershowers are forecast for the entire week, through Saturday, but, when they come, they don’t last too long, an hour at most, and then the air is clear and clean. Not crisp, but clear and clean and HUMID!
The mosquitos are thriving. It was forecasted when we had such a mild winter that the insect population would rocket, and already, barely midsummer, or at least mid-heat of summer, and dengue fever has hit in New York, Miami, and other mosquito-borne illnesses are showing up throughout Florida. Dengue fever, the article referenced above states, used to be seen only in people returning from overseas country where it was present, but now, mosquitos in the USA are carrying it. Good time to wear repellant. 🙂
Scam Attempt! Scam attempt! Magazine Subscription SCAM!
You know, I can’t help it, I take these things personally, especially when I am almost fooled.
A couple weeks ago I got a renewal notice for a magazine I take – but I remembered resubscribing; it’s a magazine I don’t want to miss! So I checked the cover of my most recent magazine, and it doesn’t expire until 2014.
Then I looked again at the renewal notice – it wasn’t actually from the publisher. And the price was very HIGH!
I threw it away.
Today I got two more renewal notices, from the same ‘subscription company.’ One was a three year renewal offer on a magazine I don’t take and would never take in a million years. The second was for a magazine I take, but at a price a lot higher than what I pay.
It just makes me so mad. These renewal offers LOOK so official. I Googled “magazine subscription scams” and found this reference where it tells about this renewal scam – and many others. It particularly warns you not to buy from people selling door-to-door; you often never see a magazine and you sure don’t see your money again, bye bye!
Barnes and Nobles: Paradise
We’d had guests, people we really like and admire, and now I was about to take them shopping. This kind of shopping is special. It is people-on-limited-budget shopping by people-who-may-never-visit-the-United-States-again and who have a lot of people hoping they will bring something back for them. We know this feeling – we’ve been those people on a limited budget who want to delight our family and friends with some exotic treasure.
I had a plan. Truthfully, I should know by now how it is going to work out, but I always plan bigger, just in case. This time, we started at TJ Maxx and The Dollar Store.
We park in a highly visible place. I know it sounds rude, but I escort them in, explain a few little things, then I go back to the car. I have a book with me, and Sudoku; they get to shop at their own pace without feeling like they are inconveniencing me. They have my phone number, and they know where the car is parked. Some groups come back and forth, many times, they bring packages, drop them, and head back again. This time, I didn’t see them, so after two hours, I went in and found them and told them this was their “one hour warning.” I had promised to have them back at their hotel by seven.
Almost on the minute one hour later, they came out, entered the car, and were so excited. One said she had finished all her shopping; she had something just right for everyone. The other said “Look! My friend wanted Bicycle cards! They had Bicycle cards!” They had found special gifts for all their friends and family, but the price was high. They had wanted to go to the Barnes and Noble store, but we had run out of time.
Deep sighs.
“It’s totally worth it,” the older one said, “I really really needed to have the peace of knowing my shopping was done. But . . . I’ve never seen the Barnes and Noble, only heard about it. Maybe I’ll have another chance at our next city . . . ”
I couldn’t bear it.
“The Barnes and Noble is only a short distance away,” I gave in, “I will take responsibility for getting you back late IF you promise me to only go in and look, just take a quick look, and come back out to the car.”
“Yes! Yes!” they both promised enthusiastically.
They were gone for twenty minutes. When they came back out, their faces were stunned. They got in the car, so silent I was afraid there was a problem.
The youngest leaned over, buried her head in her hands. She looked like she was going to be sick.
“What’s the matter?” I asked, alarmed.
“I almost feel sick,” she said. “So many books! We walked everywhere, but I stayed most of the time in the Business Management section; they had EVERYTHING. They had Who Moved My Cheese. Oh! They had so many good books, not the blah-blah-blah you get in textbooks, but the way they teach in parables, it’s so easy to understand their point. I can’t carry all the books I wanted to buy. I’m feeling shocked. All those books, right there where anyone can buy them! I want them all and I can’t have them.”
“You could order them, have them sent,” the older girl offered, and then remembered that no, she couldn’t have things sent in her country. She would never get them.
All the way to the hotel we had a great conversation about the flow of ideas, about censorship and the internet and cable television and Twitter, and how ideas flow more freely everywhere in the world, in spite of those who would try to restrict what their citizens might access. We also talked about freedom to travel – or the lack of freedom. We talked about families, caring for the elderly, and family responsibilities. We talked about what we’ve learned from one another, the truths travel teaches you about your prejudices and opinions, about others, and about yourself.
As I dropped them off, we all hugged, sadly realizing that we may never see one another again. Nonetheless, no regrets. Just the time I had with these two impressive young women was a great gift, and seeing the Barnes and Noble through their eyes – I will never again take a book shop for granted.
Emirates Women Seek Law Forcing Tourists to Dress Modestly
Qatari women have the same concerns in Qatar; this article from http://www.huffingtonpost.com/2012/07/06/emiratis-dress-code_n_1653446.html?utm_hp_ref=world:
ABU DHABI, United Arab Emirates — With the number of foreigners dwarfing that of locals in her hometown of Abu Dhabi, Asma al-Muhairi has become increasingly anxious at the prospect of her younger nieces abandoning their full-length black robes in favor of Western attire that seems to be everywhere she goes.
But it wasn’t until the 23-year-old marketing worker came face to face with two scantily-clad female foreigners at one of the many luxury shopping malls in the United Arab Emirates that she decided to take action.
“While going to a mall, I saw two ladies wearing … I can’t say even shorts. It was underwear,” said al-Muhairi, whose black abaya – a long garment worn by conservative Gulf women – is offset by a gold Versace watch and egg-shell blue handbag.
“Really, they were not shorts,” she said. “I was standing and thinking: `Why is this continuing? Why is it in the mall? I see families. I see kids around.'”
Failing to persuade the mall to intervene, al-Muhairi and another Emirati woman, Hanan al-Rayes, took to Twitter to air their concerns in May.
They were inundated with responses that prompted them to launch a Twitter campaign dubbed (at)UAEDressCode that aims to explore ways to combat the growing number of shoppers in low-cut dresses and hot pants.
As the campaign picked up steam, it also has served to symbolize the growing concerns among Emiratis, a tiny minority in their own country.
Emirati citizens account for a little more than 10 percent of the 8 million people living in the Gulf nation. Most of the population is made up of Asian, African and Middle Eastern guest workers, as well as Western expatriates living here temporarily.
The overall population more than doubled over the past decade as the country embarked on a building boom that transformed Dubai, up the coast from Abu Dhabi, into the Arabian Gulf’s financial hub and a popular tourist draw.
“I think in an increasingly tumultuous region and in an era of powerful and often intrusive globalizing forces, citizens of the UAE are increasingly concerned that their traditions and core values are being eroded,” said Christopher Davidson, an expert on Gulf affairs at Britain’s Durham University.
“In some senses, it is a grassroots reaction to authorities and leaders that have for many years done little to check this erosion,” he added. “We’ve seen reactions to alcohol, so now we are seeing a reaction to immodest dress.”
Jalal Bin Thaneya, an Emirati activist who has embraced the dress code campaign, said it is a way for Emiratis to show they are concerned about the loss of traditions.
“If we were the majority and had the same make up, things would be different,” Bin Thaneya said. “You wouldn’t need anything. You would see Emiratis everywhere and you would be afraid of offending them … Now, we’re a minority so you feel the need to reach out to an authority.”
As the number of foreigners has increased, so have the stories of them violating the UAE’s strict indecency code, which limits drinking to bars and nightclubs and bans public displays of affection. A drunken couple was caught having sex on the beach and another allegedly having sex in a taxi. A Pakistani was deported for flipping the middle finger at a motorist, and the courts are filled with cases of foreigners having sex out of wedlock.
Most Emiratis rarely come face-to-face with misbehaving foreigners.
The malls, however, are a different story.
They are one of the few places where everyone comes together to escape the brutal summer heat. The cultural clash is hard to ignore, as families of traditionally dressed Emiratis shop and relax in cafes alongside foreign women wearing tank tops, shorts and even transparent gowns over bikinis.
Most malls have policies in place that require “conservative” dress and encourage shoppers to avoid showing shoulders and knees, but few publicize them or enforce them. Police in Dubai, where the mall that al-Muhairi visited was located, didn’t respond to a request for comment. They told the Gulf News newspaper there is nothing they can do since there are no specific laws against immodest dress.
“People were seeing it for a long time but they didn’t say anything,” Bin Thaneya said. “You can’t go to the police for such stuff. There is no one to go to. You can’t go to the mall management. The mall security guard gets paid less than someone at McDonald’s. He isn’t going to do anything.”
Al-Muhairi’s campaign is just one of several over the years led by Emirati women who have tried in vain to enforce the dress code – handing out brochures, confronting foreigners. But hers has benefited from the growing popularity of social media as well as the Arab Spring popular uprisings, which has given Emiratis a sense they can speak out on some social issues.
The UAEDressCode feed has more than 3,300 followers with a lively discussion that includes plenty of support for a code but also concerns that it would unfairly target foreigners or create divisions between locals and foreigners. Unlike similar campaigns in Kuwait or Saudi Arabia, the impetus for a code has not come from Islamic hard-liners, but from moderate locals like al-Muhairi who love their Starbucks and Western movies but just want foreigners to respect local customs.
“We are not asking others to cover up like us. We are giving them freedom based on their beliefs and religion,” al-Muhairi said. “We are not judging and saying this shows she has other interests. We never want to judge. Do whatever you want and wear what you want but with limits. Just respect the public here.”
The campaign has caught the attention of the Federal National Council, which pledged last month to push for stronger measures to enforce the dress codes. That came after the country’s culture minister, Abdulrahman al-Owais, supported efforts to emphasize the conservative traditions of the UAE.
Members of a half-elected, half-appointed council have suggested a law could include warnings and fines but not jail time for offenders. But the FNC has no law-making powers, so any decision now rests with the UAE government.
“If there is a law, the behavior will be different,” said Hamad al-Rahoomi, an FNC member who compared a UAE dress code to laws in France that bans the niqab, in which a veil has only a slit exposing a woman’s eyes, or the new dress code at Royal Ascot in Britain that aims to limit provocative outfits.
“We don’t want to catch people. We just want people to think of the other parties,” al-Rahoomi said. “What I want is to go with my family in my country and not see something that is harming me.”
The Abu Dhabi police issued this week a booklet on dos and don’ts for tourists that will be available at the Abu Dhabi International Airport and hotels, according to The National newspaper. It advises tourists that public displays of affection including kissing are considered indecent and that they should wear “modest” clothing.
Tourists – some in skimpy summer dresses, others in shorts and T-shirts – defended their right to wear what they want, either because it is fashionable or keeps them cool in the summer heat. None of the 10 people interviewed in Dubai and Abu Dhabi knew about a mall dress code, nor were they advised their outfits violated it. Several said a dress code law would go too far.
“I think it’s ridiculous because most of the people in Dubai are tourists,” said Sarah, a 21-year-old tourist from Kenya wearing a short dress exposing her shoulders and legs. “I want to go somewhere where I would be comfortable in my own skin as a travel destination. I feel comfortable like this and this is how I will dress.”
Not the Day We Expected – Even Better
LOL, as our Friday dawned with thunder and lightning, our day totally changed. We had thought we would rush to our water aerobics class, rush home, hand up our clothes, head out to meet friends for Italian food near Destin, and then come home.
With the thunder and lightning, however, we knew there couldn’t be a class, and so we had an unexpected holiday from exercise, sort of puttered around the house taking care of things that needed taking care of, and headed off to meet up with our friends. We had a great time, great conversations, and they mentioned – as have other friends – how much they enjoyed The Best Exotic Marigold Hotel, and that we really needed to see it. After long, fond farewells, we headed home, via the beach, which we always love. So far, it was a much cooler day, only reaching the 80’s as we drove along, due to the cloud cover.
AdventureMan suggested we look at the GulfBreeze4, a really fun little theatre we love to go to where they show a lot of foreign movies or quirky movies that didn’t make it to the big screen, and there it was, the Best Exotic Marigold Hotel, and we were just in time for the afternoon showing.
It is a delightful movie. It has a lot of fun moments, some sad moments, many very human moments. You know me, I especially love the cross-cultural moments, and the thought that people can grow and adapt – no matter what age. We really enjoyed the movie.
And, when we left, we just had to have Indian food. We stopped at Taste of India on the way home and had Talli. It was one of those nights when almost every table was taken, but they had room for us.
“How spicy?” our favorite waitress asked.
“Spicy,” we stated emphatically.
“Oh!” she exclaimed, “Indian spicy!” and we said “Yes!”
When it came, it tasted like being back in Kuwait, eating food my friends had prepared. Not dumbed down food. Good, strong spicy food. We couldn’t even eat it all; but we know how good it will taste tomorrow. We brought a lot of it home 🙂
So it wasn’t the day we expected, but we feel blessed by the day we had. Good friends, good conversation, lots of laughing, good movie and a good time at Taste of India. A great day altogether.
Laugh and Live Longer?
Found this fascinating article today in AOL News/HuffPost.
Do those who laugh the most live the longest?
Possibly so, according to a new study in the journal Aging.
Researchers from Albert Einstein College of Medicine and Yeshiva University found that people who possess certain personality traits based in genetics may live longer lives — particularly those who are optimistic, laugh a lot and are easygoing.
The study was based on an analysis of 243 people with an average age of 97.6. These people were part of a bigger study, called the Longevity Genes Project at Albert Einstein College of Medicine, which examines 500 Ashkenazi Jews ages 95 and older (Ashkenazi Jews are genetically homogenous, researchers said), as well as 700 of their offspring.
“When I started working with centenarians, I thought we’d find that they survived so long in part because they were mean and ornery,” study researcher Dr. Nir Barzilai, M.D., director of Einstein’s Institute for Aging Research, said in a statement.
“But when we assessed the personalities of these 243 centenarians, we found qualities that clearly reflect a positive attitude towards life,” he said. “Most were outgoing, optimistic and easygoing. They considered laughter an important part of life and had a large social network. They expressed emotions openly rather than bottling them up.”
The researchers also found that the study participants scored lower on tests for neurotic personality and scored higher on tests for conscientiousness, compared with comparable scores for the U.S. population.
Last year, a study in the journal Proceedings of the National Academy of Sciences showed that older people who are happy have a 35 percent lower risk of dying over a five-year period than unhappy people. That study included 3,853 people ages 52 to 79.
“The happiness could be a marker of some other aspect of people’s lives which is particularly important for health,” study researcher Andrew Steptoe, a professor at University College, London, told The Telegraph. “For example, happiness is quite strongly linked to good social relationships, and maybe it is things like that that are accounting for the link between happiness and health.”
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