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The Hidden Dangers in Baking, Roasting, Grilling, Broiling

This is especially bad news for me; I love broiling and roasting to concentrate flavors. I love those crispy pieces of grilled foods . . . the latest from Bottom Line Publications.

How it’s cooked may increase your risk for chronic illness.

Some of the most serious chronic health problems in the US, including Alzheimer’s disease, cancer, diabetes and kidney and heart disease, have been linked to what we eat—processed foods, fast food, red meat, etc. What may surprise you is that the increased health risks from these foods may be due in large part to how they are cooked.

Dry-heat cooking, such as grilling, broiling, frying and even baking and roasting, greatly increases levels of advanced glycation end-products (AGEs), also known as glycotoxins. Small amounts of these chemical compounds are naturally present in all foods, but their levels rise dramatically when foods are subjected to dry heat, which frequently occurs both in home cooking and in commercial food preparation.

The danger: AGEs are oxidants that produce free radicals, damage DNA, trigger inflammation throughout the body and accelerate the aging process. They also make cholesterol more likely to cling to artery walls, the underlying cause of most heart attacks. Some researchers now believe that AGEs can be linked to most chronic diseases.

A century ago, people mainly ate fresh, homemade foods, such as grains, vegetables, legumes and fruits, with relatively small amounts of meat. The processed food industry was still in its infancy.

However, in the following decades, meat portions grew larger, and Americans acquired a strong desire for the intense flavors, aromas and colors in commercially prepared “browned” foods, such as crackers, chips, cookies, grilled and broiled meats, french fries, pizza, etc. During this time, the rates of heart disease, diabetes and other chronic diseases started to rise. This wasn’t a coincidence—the rich taste, smell and appearance of these foods primarily come from AGEs.

Our bodies can neutralize the small amounts of AGEs that are naturally found in foods (and that we produce as a by-product of metabolism). But our defense mechanisms are overwhelmed with the high amounts that are now very common in the typical American diet.

AGEs are measured in kilounits (kU). We recommend consuming no more than 5,000 kU to 8,000 kU per day (see box for examples of kU levels in some common foods). Recent studies have shown that the average American typically consumes more than 15,000 kU daily, and many people eat well over 20,000 kU daily.

Reducing dietary AGEs may be especially important for people with diabetes because high blood sugar levels cause more AGEs to form. It’s also crucial for people with kidney disease because they are less able to remove AGEs from the body. AGEs also are elevated in patients with heart disease, obesity and dementia.

Researchers can measure the amounts of AGEs in the blood, but doctors don’t commonly use this test because it’s not currently available for commercial use. What your doctor can do is measure levels of C-reactive protein (CRP), a marker for inflammation. If your level is high (above 3 mg/dL), you may have excessive AGEs in your blood. If you eat a lot of grilled, broiled and roasted meats, for example, and/or heat-treated processed foods, this also means your AGE levels are likely too high.

Our studies have shown that people who make simple dietary changes can reduce their levels of AGEs by more than 50% in four months. The reduction is accompanied by a similar decrease in CRP levels. Helpful strategies…

Eat less animal protein. Animal protein, especially red meat, is among the main sources of AGEs—and the levels can multiply tenfold when the meat is grilled, broiled, baked or roasted. Helpful: Eat beef no more than three times a week.

Because animal fat also contributes to AGE intake, eat lean meats. They have fewer AGEs than higher-fat meats. Animal fats such as butter also are higher in AGEs than plant fats such as olive oil.

Best approach: Fill three-quarters of your plate with plant foods, such as vegetables, whole grains, legumes and fruits, and leave no more than one-quarter of the plate for animal foods, such as meats and cheeses.

Soups and stews are tasty ways to serve small portions of meat. Also enjoy more meatless meals, such as vegetarian chili or veggie burgers. Nonfat milk and yogurt are low in AGEs and are a good way to add protein to meals and snacks.

Avoid dry-heat cooking, such as grilling, broiling, baking, roasting and frying. High, dry heat greatly increases AGEs. Example: A piece of raw meat might have 500 kU to 700 kU of AGEs. But after the meat is broiled, the level can rise to 5,000 kU to 8,000 kU.
Better approach: Cook with moist heat—stew, poach, steam, boil or microwave. A piece of chicken that’s poached or boiled, for example, will have about 1,000 kU. The same piece of chicken will have about 5,000 kU when it’s broiled.

If you have a desire for grilled or roasted foods, vegetables and fruits are better choices than meats. These foods have far fewer AGEs than meats and fats when cooked with dry heat.

If you do cook with dry heat, marinate first. The eventual formation of AGEs is reduced by about 50% when raw meats are marinated in acidic ingredients, such as vinegar or lemon juice. For each pound of meat, use the juice from two lemons or an equivalent amount of vinegar or lime juice plus enough water to cover the meat (about one cup). Add some garlic and/or herbs for extra flavor. Avoid commercial marinades since they’re usually high in sugar and/or oil, which will increase AGEs.

Reheat gently. Microwaving is a good method for reheating meats and other foods. Be sure to include plenty of liquid and reheat to a safe temperature to prevent the possibility of food-borne illness due, for example, to E. coli or salmonella.

Soups, sauces and gravies should be brought to a boil. Leftovers such as meats and casseroles should be reheated to 165°F.

Don’t eat certain foods together. Consuming meats with foods that are high in sugar—for example, having a slice of cake after eating a hamburger—allows existing AGEs in the meat to interact with the sugars in the cake, creating higher levels of AGEs.

Similarly, eating meats with very high-fat foods, such as a hamburger topped with bacon and cheese, will produce far more AGEs than consuming these foods by themselves.
Focus on fresh foods. Because processed foods have high levels of AGEs, fresh foods and foods that have been minimally processed are a much better choice.

A serving of rice, for example, will have almost no AGEs, but the same amount of crispy rice cereal will have 600 kU. Avoid takeout and convenience foods, such as fast-food burgers, fries and pizza.

Warning: Any food that has been browned or crisped, such as cookies, crackers, chips, etc., will be high in AGEs.

Sources: Sandra Woodruff, RD, a registered dietitian and nutrition consultant based in Tallahassee, Florida, and Helen Vlassara, MD, an endocrinologist and professor at Mount Sinai School of Medicine in New York City, where she directs the Experimental Diabetes and Aging Division. They are coauthors of The AGE-Less Way: Escape America’s Overeating Epidemic. (

October 1, 2012 - Posted by | Aging, Cooking, Experiment, Food, Safety


  1. It’s a bit late for me, but I just turned 100% vegan, a lesson learnt the hard way 😛

    Comment by GreY | October 1, 2012 | Reply

  2. You know, GreY, I am not there yet. I’m sorry you had to come to it in such a painful and frightening way. In Bible Study, however, we are studying Genesis, (in great depth) and in verse 1:29 God says “I give you every seed bearing plant on the face of the whole earth and every tree that has fruit with seed in it. They will be yours for food.”

    It makes you stop and think. Maybe that is what we are supposed to be eating? I know later in this book, people begin making offerings to him, first fruits, and that the burning fat and cooked meat makes a fragrant odor offering to him, but I wonder if it ever says we are to eat meat? Just pondering . . .

    Comment by intlxpatr | October 1, 2012 | Reply

    • Even in Daniel chapter 1 it says ” 11 Daniel then said to the guard whom the chief official had appointed over Daniel, Hananiah, Mishael and Azariah, 12 “Please test your servants for ten days: Give us nothing but vegetables to eat and water to drink. 13 Then compare our appearance with that of the young men who eat the royal food, and treat your servants in accordance with what you see.” 14 So he agreed to this and tested them for ten days.

      15 At the end of the ten days they looked healthier and better nourished than any of the young men who ate the royal food. 16 So the guard took away their choice food and the wine they were to drink and gave them vegetables instead.”

      I really feel bad because I was so utterly ignorant about what I ate 😦 I was not told about the evils of junk food / sugar, but I am trying to educate my son.

      Comment by GreY | October 1, 2012 | Reply

  3. GreY, don’t feel bad, we all do the best we can. And current thinking changes, although I suspect that we really aren’t meant to be eating so much meat. We knew sugar was bad for us, but fish? I always thought fish was GOOD for us! I’m not sure I can give up salmon . . . 🙂 The film you published is life-changing . . .

    Comment by intlxpatr | October 1, 2012 | Reply

  4. How can salmon be cooked in a proper way?

    Comment by Ann Page | July 30, 2022 | Reply

    • Ann, I still like to pan fry my salmon in olive oil with a thin coat of flour. I like it crisp on the outside and soft and buttery on the inside. We also make salmon patties. If you want a healthier method, I have cooked salmon in paper, also baked it in a crust. It can be beautiful if you are entertaining. We also like smoked salmon in angel hair pasta. We eat a ot of salmon!

      Comment by intlxpatr | July 31, 2022 | Reply

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